We've found that BPC 157 doesn't change structural issues in 99% of cases. So, if you have a large disc herniation pinching a nerve root, BPC 157 is usually ineffective., However, if your pain is from Breakthrough Peptide Healing: How BPC 157 & TB 500 Support Rapid Recovery at Iowa IV Iowa IV Can BPC 157 Heal a Herniated Disc? What Patients With Back Pain Should Know Does the BPC 157 Peptide Work? Regenexx at New Regeneration Orthopedics